Keelin Flynn

Keelin obtained a B.Sc in Pharmacology from University College Dublin in 2019. Her final year project involved the generation of kidney and brain organoids to investigate whether epigenetic silencing plays a role in mediating renal damage.  She gained useful skills in cell culture when carrying out her final year project that she has been able… Read More

Dr Aisling O’Brien

Aisling completed her BSc in Biomedical Science at Dublin Institute of Technology, Kevin St in 2015 and began her PhD with the Obesity Immunology Research group under the supervision of Prof. Donal O’Shea and Dr. Andrew Hogan at St. Vincent’s University Hospital. Her research focused on the impact of obesity on Mucosal -Associated T (MAIT)… Read More

Siobhan C. Wade M.Sc

Siobhan Wade is currently the Lab Manager for the Molecular Rheumatology group. Siobhan completed a four year BA in Immunology in 2013 here in Trinity College Dublin, undergoing a final year research project with the School of Biochemistry and Immunology, supervised by Dr. Emma Creagh. Following this, she continued her research studies with Dr. Creagh… Read More

Distinct Endothelial cell transcriptional regulation and function

Rheumatoid Arthritis and Psoriatic Arthritis are two of the most common forms of Inflammatory arthritis. While both are associated with synovial inflammation and subsequent cartilage/bone destruction, the mechanisms involved are different. A number of studies have demonstrated distinct differences in the macroscopic and microscopic analysis of RA and PsA, with particular reference to the distinct… Read More

Distinct pathogenic mechanisms in Downs Arthritis and Juvenile Idiopathic Arthritis

Down’s syndrome (DS) is a chromosomal disorder caused by an extra chromosome 21.  Immune dysregulation predisposes children with DS to high incidences of autoimmune diseases. DA is an inflammatory joint condition affecting children with DS, which is under-recognised, has a delayed diagnosis, resulting in chronic disability. Our clinical research showed an increased risk of arthritis… Read More

To identify molecular signatures in monocyte/macrophages that can predict disease onset in ‘at-risk ACPA+’ individuals and disease progression in RA

Recent research has focused on people ‘at-risk’ of RA with circulating autoantibodies (ACPA/RF) but no clinical signs of RA currently.  These subjects may provide important clues in understanding the evolution of RA. Identifying those ‘at-risk’ remains problematic, with no good blood or tissue biomarkers identified to date. However, we and others, have demonstrated that circulating… Read More

Centre for Arthritis and Rheumatic Diseases

CARD rheumatology at St Vincent’s University Hospital is a EULAR Centre of Excellence for research and education. Our main focus is on patients with early, inflammatory arthritis eg. rheumatoid / psoriatic and vasculitis eg. Giant Cell Arteritis. We aim to provide patients with state-of-the-art treatment and information about their conditions. Our key scientific focus is on understanding… Read More

Tallaght Hospital Partnership

In 2017, Prof. Ronan Mullan designed and implemented an ultrasound guided biopsy programme in the Bone and Joint Unit, Tallaght Hospital. In collaboration with Prof. Ursula Fearon, Ms. Sian Cregan implemented the first wet-lab tissue culture programme at Tallaght Hospital, utilizing the facilities provided by the newly refurbished Meath Foundation Research Laboratory. The on-site translational molecular… Read More