2018

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Enriched Cd141+ DCs in the joint are transcriptionally distinct, activated, and contribute to joint pathogenesis.

Canavan M, Walsh AM, Bhargava V, Wade SM, McGarry T, Marzaioli V, Moran B, Biniecka M, Convery H, Wade S, Orr C, Mullan R, Fletcher JM, Nagpal S, Veale DJ, Fearon U. JCI Insight. 2018 Dec 6;3(23). pii: 95228.

Standardisation of synovial biopsy analyses in rheumatic diseases: a consensus of the EULAR Synovitis and OMERACT Synovial Tissue Biopsy Groups.

Najm A, Le Goff B, Orr C, Thurlings R, Cañete JD, Humby F, Alivernini S, Manzo A, Just SA, Romão VC, Krenn V, Müller-Ladner U, Addimanda O, Tas SW, Stoenoiu M, Meric de Bellefon L, Durez P, Strand V, Wechalekar MD, Fonseca JE, Lauwerys B, Fearon U, Veale DJ; EULAR Synovitis Study Group and OMERACT Synovial Tissue Special Interest Group.Arthritis Res Ther. 2018 Dec 3;20(1):265

Autoimmune and angiogenic biomarkers in autoimmune atherosclerosis.

Balogh E, Pusztai A, Hamar A, Végh E, Szamosi S, Kerekes G, McCormick J, Biniecka M, Szántó S, Szűcs G, Nagy Z, Fearon U, Veale DJ, Szekanecz Z. Clin Immunol. 2018 Dec 10. pii: S1521-6616(18)30721-6

Novel gene targets for miRNA146a and miRNA155 in anterior uveitis.

O’Rourke M, Trenkmann M, Connolly M, Fearon U, Murphy CC. Br J Ophthalmol. 2018 Oct 8. pii: bjophthalmol-2018-312885

Altered expression of microRNA-23a in psoriatic arthritis modulates synovial fibroblast pro-inflammatory mechanisms via phosphodiesterase 4B.

Wade SM, Trenkmann M, McGarry T, Canavan M, Marzaioli V, Wade SC, Veale DJ, Fearon U. J Autoimmun. 2018 Sep 1. pii: S0896-8411(18)30338-X. doi: 10.1016/j.jaut.2018.08.008. [Epub ahead of print]

Altered metabolic pathways regulate synovial inflammation in rheumatoid arthritis.

Fearon U, Hanlon MM, Wade SM, Fletcher JM. Clin Exp Immunol. 2018 Oct 25. doi: 10.1111/cei.13228.

The Utility and Limitations of CRP, ESR and DAS28-CRP in Appraising Disease Activity in Rheumatoid Arthritis.

Orr CK, Najm A, Young F, McGarry T, Biniecka M, Fearon U, Veale DJ. Front Med (Lausanne). 2018 Aug 3;5:185. doi: 10.3389/fmed.2018.00185. eCollection 2018.

Interleukin 12 and interleukin 23 play key pathogenic roles in inflammatory and proliferative pathways in giant cell arteritis.

Conway R, O’Neill L, McCarthy GM, Murphy CC, Fabre A, Kennedy S, Veale DJ, Wade SM, Fearon U, Molloy ES. Ann Rheum Dis. 2018 Aug 10. pii: annrheumdis-2018-213488. doi: 10.1136/annrheumdis-2018-213488. [Epub ahead of print]

The pathogenesis of psoriatic arthritis.

Veale DJ, Fearon U. Lancet. 2018 Jun 2;391(10136):2273-2284. doi: 10.1016/S0140-6736(18)30830-4. Epub 2018 Jun 1. Review.

Oxidative stress impairs energy metabolism in primary cells and synovial tissue of patients with rheumatoid arthritis.

Balogh E, Veale DJ, McGarry T, Orr C, Szekanecz Z, Ng CT, Fearon U, Biniecka M. Arthritis Res Ther. 2018 May 29;20(1):95. doi: 10.1186/s13075-018-1592-1.

JAK-STAT blockade alters synovial bioenergetics, mitochondrial function and pro-inflammatory mediators in Rheumatoid arthritis.

McGarry T, Orr C, Wade S, Biniecka M, Wade S, Gallagher L, Low C, Veale DJ, Fearon U. Arthritis Rheumatol. 2018 May 23. doi: 10.1002/art.40569. [Epub ahead of print]

Ustekinumab for refractory giant cell arteritis: A prospective 52-week trial.

Conway R, O’Neill L, Gallagher P, McCarthy GM, Murphy CC, Veale DJ, Fearon U, Molloy ES. Semin Arthritis Rheum. 2018 Apr 22. pii: S0049-0172(17)30808-9. doi: 10.1016/j.semarthrit.2018.04.004. [Epub ahead of print]

The pathogenic role of dendritic cells in non-infectious anterior uveitis.

O’Rourke M, Fearon U, Sweeney CM, Basdeo SA, Fletcher JM, Murphy CC, Canavan M. Exp Eye Res. 2018 Aug;173:121-128. doi: 10.1016/j.exer.2018.05.008. Epub 2018 May 25.

Integrative analysis reveals CD38 as a therapeutic target for plasma cell-rich pre-disease and established rheumatoid arthritis and systemic lupus erythematosus.

Cole S, Walsh A, Yin X, Wechalekar MD, Smith MD, Proudman SM, Veale DJ, Fearon U, Pitzalis C, Humby F, Bombardieri M, Axel A, Adams H 3rd, Chiu C, Sharp M, Alvarez J, Anderson I, Madakamutil L, Nagpal S, Guo Y. Arthritis Res Ther. 2018 May 2;20(1):85. doi: 10.1186/s13075-018-1578-z.

Hypoxia, oxidative stress and inflammation.

McGarry T, Biniecka M, Veale DJ, Fearon U. Free Radic Biol Med. 2018 Mar 27. pii: S0891-5849(18)30145-X. doi: 10.1016/j.freeradbiomed.2018.03.042. [Epub ahead of print] Review.

Knee joint synovitis: study of correlations and diagnostic performances of ultrasonography compared with histopathology.

Najm A, Orr C, Gallagher L, Biniecka M, Gaigneux E, Le Goff B, Fearon U, Veale DJ. RMD Open. 2018 Feb 8;4(1):e000616. doi: 10.1136/rmdopen-2017-000616. eCollection 2018.

Immune checkpoint inhibitor PD-1 pathway is down-regulated in synovium at various stages of rheumatoid arthritis disease progression.

Guo Y, Walsh AM, Canavan M, Wechalekar MD, Cole S, Yin X, Scott B, Loza M, Orr C, McGarry T, Bombardieri M, Humby F, Proudman SM, Pitzalis C, Smith MD, Friedman JR, Anderson I, Madakamutil L, Veale DJ, Fearon U, Nagpal S. PLoS One. 2018 Feb 28;13(2):e0192704.