Hannah has been a Research Assistant for the Molecular Rheumatology Research Group and an employee of CARD since June 2016. Primarily, she coordinates our weekly arthroscopies and liaises with our research team to confirm sample collection and processing. She also assists the research team with any experimental procedures that need doing. Hannah obtained her Undergraduate… Read More
Sian graduated from NUI Maynooth with a B.Sc in Genetics and Bioinformatics in 2011. Subsequently, she studied an M.Sc in Translational Oncology with Trinity College Dublin, where she developed an interest in epigenetics in inflammatory diseases. Sian has recently completed her research M.Sc which investigated the mechanism of action of Methotrexate on inflammatory mechanisms in… Read More
Dr Viviana Marzaioli is a Principal Investigator within the Molecular Rheumatology group in the Trinity Biomedical Sciences Institute (TCD). Her research focuses on investigating the contribution of innate immunity in the initiation and the progression of Rheumatoid and Psoriatic arthritis, with an emphasis on the dysregulation in monocyte-derived cells development. Her research goal is to… Read More
Lorna obtained her PhD from National University of Ireland, Maynooth in the area of molecular microbiology with Prof. Sean Doyle in 2010. Her first postdoctoral position was with Dr. Chet Cooper in the Dept. of Biology, Youngstown State University, Ohio. She then returned to Ireland to work with Prof. Ursula Bond in the Dept. of… Read More
Sarah was awarded a BSc in Biomedical Health and Life Sciences from University College Dublin in 2013 with an experimental thesis entitled “Pathogenic Potential of MicroRNA in Giant Cell Arteritis”. Sarah’s experience in translational research led her to a strong interest in physiologically relevant models of disease to better understand disease mechanisms and potential therapeutic… Read More
Tatsiana obtained her PhD from Trinity College Dublin in Biochemistry, in the area of tRNA modification with Prof. Vincent Kelly in 2011. She undertook her first postdoctoral position with Prof. Yuri Volkov (2010-2014) in the Nanomedicine group in St. James’s Hospital, Trinity College Dublin. While there, she was involved in NAMDIATREAM (Nanotechnological toolkits for multi-modal… Read More
Clare completed a B.A (Mod) in Biochemistry and Immunology at Trinity College Dublin in 2011 and began a PhD under the supervision of Dr Aisling Dunne in the Molecular Immunology Group, TCD. Her research focused on the role of particulate matter in driving joint inflammation and tissue degradation with particular attention to the intracellular signalling… Read More
Monika was awarded a PhD in Endocrinology from Jagiellonian University in 2005. Since 2007 she is a postdoctoral scientist in the Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre in St Vincent’s University. She is also a visiting research fellow in the Department of Molecular Rheumatology, Trinity College Dublin. Her research projects were… Read More
Sharon obtained her PhD in Regenerative Medicine from NUI Galway under the supervision of Dr. Mary Murphy. During her PhD, Sharon was successful in obtaining a Fulbright Scholarship and Osteoarthritis Research Society International Scholarship which enabled her to carry out a 9 month research placement at the Center for Musculoskeletal Research, University of Rochester, New… Read More
Achilleas obtained his Ptyxio (BSc+ Diploma) in molecular Biology by the University of Crete, Greece in 2010. In the same year Achilleas received a PhD studentship by the Institute of Molecular Medicine of Newcastle University, UK. During this time he worked on the role of B cells in the liver autoimmune disease Primary Biliary Cirrhosis… Read More
Trudy obtained her BSc in Biomedical Health and Disease from University College Dublin in 2011. In the same year, Trudy was awarded a Molecular Medicine Ireland PhD scholarship for their unique cross-institutional Clinical and Translation Research Scholars Programme (CTRSP). During her PhD, she completed a four month Industry internship with Quintiles Transnational as part of… Read More
This study is investigating the Immunology and Histopathology of Inflammatory Arthritis in Children with Down syndrome. Approximately 110 babies with Down syndrome are born in Ireland each year, making Ireland’s birth rate of children with Down syndrome the highest in Europe. A variety of medical conditions and immunological abnormalities are associated with Down syndrome. Immune… Read More
Inflammatory Arthritis is a common autoimmune disease which causes joint tissue destruction, work instability due to disability and ultimately premature mortality. In addition, IA reduces mobility, increases social isolation and is significantly associated with obesity and diabetes. Targeted biotherapeutics have a major effect on the outcome of IA, however responses may be sub-optimal or associated… Read More
Molecular Rheumatology (TCD) and The Centre for Arthritis and Rheumatic diseases (SVUH, UCD) have developed a number of industry partnerships around drug discovery and translational research. These studies utilize the ex vivo whole tissue synovial explant model, sorted synovial cells and multiplex protein assays, transcriptomics and a systems biology approach to establish pre-clinical drug development… Read More
Angiogenesis is an early event in arthritis, dependent on endothelial cell (EC) mitosis, migration, and organisation of primitive angiotubes. In arthritis, the new vessel network and leukocyte extravasation transforms synovial tissue (ST) into an aggressive tumor-like ‘pannus’ mediating cartilage destruction. We have previously shown that distinct vascular morphologic phenotypes exist between different arthropathies, effects that… Read More
Our group are involved with the Arthritis Research Coalition Biobank, the primary aim of which is to recruit patients with common rheumatic diseases and obtain biosamples that will underpin clinical research. A secondary aim is to increase national involvement in clinical trials of novel therapeutic agents. http://www.molecularmedicineireland.ie/research/arthritis-research-coalition/
Dendritic cells are a heterogeneous group of antigen presenting cells that link the innate and adaptive immune system. Due to their unique role in controlling naïve T cell responses, DC and subsequent T cell responses are hypothesised to be involved in the pathogenesis of RA and PsA. Indeed, the strongest evidence to suggest that DC… Read More
Psoriatic Arthritis (PsA) is a chronic autoimmune disease characterised by synovial inflammation and progressive destruction of articular cartilage and bone, with significant impact on quality of life. While advances in therapies have dramatically improved prognosis, a significant proportion of patients do not respond, have sub-optimally responses or experience adverse events. Hence, a greater understanding of… Read More
Molecular Rheumatology, Trinity College Dublin 