Vacancies

Post Doctoral Research Postions Available in our Molecular Rheumatology Group!!

Molecular Rheumatology, Trinity Biomedical Sciences Institute, TCD (https://rheumatologytcd.com) is seeking to appoint  Two Post-Doctoral Fellow (2 years) to examine the underlying molecular mechanisms mediating immune-stromal cell interactions which are critically involved in driving  inflammatory responses in Autoimmune Rheumatic Diseases.

Project Description: Inflammatory arthritis is a chronic autoimmune disease, the pathogenesis of which involves complex cellular interactions and networks of various cytokines that trigger the synovium to transform into a ‘tumor-like’ pannus, which invades both cartilage and bone, resulting in functional disability. In this project we will specifically focus on monocyte/macrophage-synovial fibroblast interactions and examine (i) functional, metabolic and transcriptional regulation between immune and stromal cells and (ii) examine the potential of targeting newly identified pathways in novel co-culture models and in ex-vivo whole tissue synovial explant models. This project will allow deeper understanding of the specific cellular, metabolic, molecular and functional dysregulation at the site of inflammation, in addition to examining the role for metabolic re-programming in the resolution of inflammation.

Applications are invited with experience in the areas of cell biology, immunology, biochemistry,  molecular biology, physiology or a related discipline. Key techniques in this project include, primary cell culture, molecular biology, flow cytometry, ELISA/MSD assays, metabolic assays and imaging. Practical experience in some of these skills would be desirable.

The positions are for 2 years and  post-doctoral salaries will be on the IUA Scale, on the  PD1 level- point 3-6; €54,936-€59771 (salary inclusive of pension/PRSI) or PD2 level-point 1-4; €61,470-€66,881 (salary inclusive of pension/PRSI) depending on experience

Informal enquiries to Prof Ursula Fearon, fearonu@tcd.ie, Molecular Rheumatology, TCD (https://rheumatologytcd.com)

How to Apply: The candidate should apply directly to WADESI@tcd.ie along with a detailed CV and cover note.