Vacancies

Research Assistant Position in Molecular Rheumatology

A research assistant position is now available in the Molecular Rheumatology Group, TCD. The main focus of the research is to investigate the key mechanisms involved in synovial invasion, immune cell dysfunction, metabolism and joint destruction.

Standard Duties and Responsibilities

– Ordering and e-procurement (Raise purchase orders and track and process the payment of invoices)

– Biobanking and data management

– Sample processing and cell culture

– Support current research team with experimental procedures

– Organise the transport of samples with industry partners

– Liaise with clinical colleagues regarding patient samples

– Maintain laboratory stocks and equipment

Knowledge and Experience (Essential and Desirable):

The researcher will work closely with other members of a multidisciplinary project team and with international scientific collaborators so strong written and oral communication skills are required. Excellent organisational and project management skills together with the ability to work on a number of projects simultaneously is essential. The ability to prioritize tasks and meet deadlines with minimal supervision whilst maintaining high levels of accuracy coupled with attention to detail is also essential. The candidate must demonstrate proven ability in developing and maintaining budgets and databases through the use of Excel.

The applicant must

– Have an interest in research and work well in a multidisciplinary group.

– Have experience with cell culture, immunohistochemistry and ELISA.

– Work collaboratively across function to ensure seamless delivery of goals. 3

– Work effectively in a climate of changing priorities in a flexible manner and supports team to do the same.

– Able to handle multiple tasks with varying complexity levels.

– Adopt a can-do attitude, anticipating and solving problems quickly and efficiently.

– Display self-motivation, resilience and have the capacity to manage their own time

– Experience using Oracle and ORION TCD IT systems is desirable

Qualifications

A degree in a Biological Science subject or related field practical skills are encouraged to apply.

Skills & Competencies

– Good organisational, communication and team working skills.

– High levels of initiative and self-motivation are essential. – Experience of working within large research projects/programmes.

– Experience in relevant collaborative research studies, and at least preliminary experience with research study database design, data analysis and data interpretation

– Good scientific writing skills and command of the English language.

– Knowledge of GDPR issues pertaining to clinical research.

Salary Range (€32,000 – €36,000) depending on experience.

Informal enquiries to Prof Ursula Fearon, fearonu@tcd.ie.

How to Apply: The candidate should submit a cover letter together with a full Curriculum Vitae to include the names and contact details of 2 referees (including email addresses) to: Ursula Fearon (fearonu@tcd.ie).

The closing date for receipt of completed applications is September 30th 2022

2x Postdoctoral Fellow Positions based between Molecular Rheumatology TCD
and the Centre for Arthritis and Rheumatic Diseases UCD

Molecular Rheumatology, TCD (https://rheumatologytcd.com) and the Centre for Arthritis and Rheumatic
Diseases, SVUH, UCD (https://arthritissvuh.com/) are seeking to appoint 2 Post-Doctoral Fellows in a dynamic research environment to perform research focused on examining the molecular pathways that
govern immune-stromal cell interactions in autoimmune diseases.

Project Summary: Project Summary: Rheumatoid arthritis (RA) is a chronic progressive inflammatory autoimmune disease characterised primarily by joint damage and disability, although it may also be associated with vasculitis and lung and heart disease. In the last two decades, targeted biotherapeutics have become highly successful in the treatment of RA with significantly improved outcomes. Despite this, a significant proportion of patients have sub-optimal responses, no response or suffer adverse events limiting the therapeutic impact. Currently we cannot predict who will develop RA, or the optimal time for treatment. Recent research has focussed on ‘individuals at-risk’ (IAR) of RA, who are positive for rheumatoid factor and/or anti-citrullinated protein antibodies but who have not developed clinical signs of arthritis, who may provide important clues in understanding the evolution of RA. Furthermore, recent studies have shown that checkpoint inhibitors which activate immune cells to attack cancer cells, can also result in uncontrolled immune responses leading to check-point inhibitor induced arthritis. Therefore, this project will perform detailed mechanistic studies of synovial tissue and cells from ‘IAR’, checkpoint-inhibitor ‘IAR’ and established RA to define (i) immune cell function, (ii) transcriptional regulation and (iii) epigenetics through the evolution of RA.

Furthermore, in collaboration with industry partners we will test potential pipeline drugs in our ex vivo 2D/3D synovial tissue models, to identify new drug candidates for the treatment of RA at the earliest stages, including potential prevention of disease. Furthermore, it will give the appointed post-docs significant insight into drug development in ‘pre-clinical proof of concept studies’ in the industry setting. The overall goal of these projects is to enable selection of the correct treatment for specific patients (precision medicine) from the outset based on a sound, scientific rationale, which in turn will impact significantly on patient care, efficiency and cost effectiveness in our healthcare system.

Applicants are invited with experience in the areas of cell biology, immunology, molecular biology, biochemistry, bioinformatics or a related discipline. Applicants should have a strong interest in translational research, Key techniques in this project include, primary cell culture, molecular biology, flow cytometry, ELISA/MSD assays, 2D/3D cultures, and scRNAseq/bioinformatics. Practical experience in some of these skills would be desirable.

The post-doctoral salary will be on the IUA Scale Level PD1 (point1-6) / PD2 (point 1-2) scale-(including PRSI and pension) depending on experience.


Informal enquiries to Prof Ursula Fearon, fearonu@tcd.ie, Molecular Rheumatology, TCD
(https://rheumatologytcd.com) or Prof Douglas Veale ( (https://arthritissvuh.com/).

How to Apply: The candidate should apply directly to fearonu@tcd.ie along with a detailed CV and cover
note.
The closing date for receipt of completed applications is September 30th 2022